THE ACTIONS OF DRUGS ON THE GUINEA-PIG ISOLATED ILEUM
Project description
1. Supplied with a spreadsheet of all the class results. Fill in the table (see next page) for all 4 types of agonist/antagonist combination used. Using appropriate
statistical tests on the class data, examine whether in each case the presence of the antagonist increased the log EC50 value of the agonist significantly (in other
words, made it less negative)*. You may use a calculator or a computer program to do the statistics. Indicate on the table the results that are significant
statistically.
* Note: the statistical tests you use should be done on the log EC50 values, rather than EC50 values, because it is only the log EC50 values that have an approximately
Normal (bellshaped) distribution; in contrast, the EC50 values usually have a skewed distribution. Many (though not all) statistical tests are valid only if the data
are approximately Normally
distributed.
2. This question tests your understanding of the practical and the relationship between agonists and antagonists. From your knowledge of the pharmacology of the
agonists that were used, and the observed changes in the EC50 values from each of the 4 drug combinations:
(i) To which drug classes do antagonists X and Y belong (i.e. which receptor types do you
think they act upon)?
(ii) With reference to the class practical results in the table (page XX), describe in detail
what the experimental evidence is for your answers to question 3(i). This justification
of your conclusions is a very important part of this practical write-up.
(iii) After using a pharmacology text book and your lecture notes, write down a possible
name for drug X and a possible name for drug Y.
3. The experimental protocol for this practical involved determining two log concentration
response curves, the first one in the absence of the unknown antagonist and the second one
in its presence. Could this experimental protocol lead to any error and, if so, and how might it be avoided (e.g. by modifying the protocol)?
Your write-up should consist of the table, and the answers to the above questions. The written answers should be typed, if possible, and should be no more than 2 side
of A4 paper (use 12 point text, double line spacing). Be brief – marks will be deducted for rambling answers that do not stick to the point. Qu 1, 6 marks; Qu 2, 8
marks; Qu 3, 2 marks.
PLACE THIS ORDER OR A SIMILAR ORDER WITH US TODAY AND GET AN AMAZING DISCOUNT ?
Our Service Charter
-
Excellent Quality / 100% Plagiarism-Free
We employ a number of measures to ensure top quality essays. The papers go through a system of quality control prior to delivery. We run plagiarism checks on each paper to ensure that they will be 100% plagiarism-free. So, only clean copies hit customers’ emails. We also never resell the papers completed by our writers. So, once it is checked using a plagiarism checker, the paper will be unique. Speaking of the academic writing standards, we will stick to the assignment brief given by the customer and assign the perfect writer. By saying “the perfect writer” we mean the one having an academic degree in the customer’s study field and positive feedback from other customers. -
Free Revisions
We keep the quality bar of all papers high. But in case you need some extra brilliance to the paper, here’s what to do. First of all, you can choose a top writer. It means that we will assign an expert with a degree in your subject. And secondly, you can rely on our editing services. Our editors will revise your papers, checking whether or not they comply with high standards of academic writing. In addition, editing entails adjusting content if it’s off the topic, adding more sources, refining the language style, and making sure the referencing style is followed. -
Confidentiality / 100% No Disclosure
We make sure that clients’ personal data remains confidential and is not exploited for any purposes beyond those related to our services. We only ask you to provide us with the information that is required to produce the paper according to your writing needs. Please note that the payment info is protected as well. Feel free to refer to the support team for more information about our payment methods. The fact that you used our service is kept secret due to the advanced security standards. So, you can be sure that no one will find out that you got a paper from our writing service. -
Money Back Guarantee
If the writer doesn’t address all the questions on your assignment brief or the delivered paper appears to be off the topic, you can ask for a refund. Or, if it is applicable, you can opt in for free revision within 14-30 days, depending on your paper’s length. The revision or refund request should be sent within 14 days after delivery. The customer gets 100% money-back in case they haven't downloaded the paper. All approved refunds will be returned to the customer’s credit card or Bonus Balance in a form of store credit. Take a note that we will send an extra compensation if the customers goes with a store credit. -
24/7 Customer Support
We have a support team working 24/7 ready to give your issue concerning the order their immediate attention. If you have any questions about the ordering process, communication with the writer, payment options, feel free to join live chat. Be sure to get a fast response. They can also give you the exact price quote, taking into account the timing, desired academic level of the paper, and the number of pages.